OPTIMIZATION OF METHODS FOR DIAGNOSTIC PLACENTAL DYSFUNCTION IN PREGNANT WOMEN

The aim of the study: to find effective and reliable predictors early diagnosis placental dysfunction.
 Materials methods. To solve tasks, we conducted a study 60 pregnant women (the main group) with dysfunction. control group consisted 30 physiological course pregnancy, who gave birth live full-term children weight growth characteristics according gestation period. state fetoplacental complex was studied based on levels hormones (PAPP-A, B-chorionic gonadotropin (B-hCG), progesterone, lactogen). biophysical fetus (BPP). uteroplacental hemocirculation, blood flow spectra were recorded in uterine arteries, umbilical basin middle cerebral artery (MCA) fetus. For each vessel, pulse index (PI), resistance (IR) systole calculated -diastolic ratio (S/D).
 Results discussion. Based analysis anamnestic data dysfunction, factors that indicate development pathology are highlighted. As result research search for dysfunction evaluation their effectiveness, it established level human chorionic decreased by 1.3 times, progesterone serum at 10-11 weeks 1.2 compared reduction lactogen. Therefore, such signs CTG, as decrease amplitude oscillations less than 3 beats/min, absence accelerations, appearance decelerations, pronounced fetal hypoxia require timely treatment solution issue childbirth. With Doppler arteries veins, found characteristic sign violation velocity curve is diastolic component dicrotic notch diastole phase.
 Conclusions. analysis, gonadotropin, PAPP-A, utero-placental disorders, advisable conduct dynamic recording cardiotocography, ultrasound fetometry placentometry, evaluate dopplerometry vessels artery. It these markers has high predictive value makes possible not only predict but also diagnose adequate manner.